Side Effects I've Experienced with Talquetamab - myelomablog Known as a bispecific T-cell engager antibody, this treatment is a relatively new kind of immunotherapy approach. New blood cancer therapy successful in three-quarters of trial patients Just under three-quarters of participants given a lower or higher dose of talquetamab in the Phase 2 portion of J&Js study responded to treatment, with around a third of each group achieving remission of their cancer. These findings were presented by Ajai Chari, MD, and colleagues at the 2022 American Society of Hematology (ASH) Annual Meeting and Exposition (Abstract 157). Hydrate, hydrate, hydrate, she said. With bispecific antibodies, the way we give . A low blood cell count, called cytopenia, was among the most common adverse events . After initial priming, patients received either weekly or biweekly dosing throughout the study duration. And then there's another variety of CAR-T cell toxicity called neurologic toxicity, which has been really tough to handle in the rare cases where it's severe. Other than some minor fatigue and some of the normal side effects of being 66, Im feeling great! Talquetamab, a bispecific antibody against CD3 and GPRC5D, redirects T cells to mediate killing of GPRC5D-expressing myeloma cells. We are getting into the realm of treatment in myeloma where the newer drugs are sometimes coming up with unique side effects. The researchers said very few patients (5 to 6 percent) stopped talquetamab treatment because of side effects. Intuitive Surgical collects new prostate procedure clearances for its single-port robot. with 8600 Rockville Pike Talquetamab is an IgG4 Fc-containing BsAb targeting G- protein-coupled receptor family C group 5 member D . James J. Driscoll, MD, PhD, and James Ignatz-Hoover, MD, PhD, share a perspective on a study published recently in ONCOLOGY. So patients, hopefully, will have a new and very exciting different opportunity coming up for the treatment of relapsed or refractory multiple myeloma. Background: 2021 Aug 21;398(10301):665-674. doi: 10.1016/S0140-6736(21)01338-6. Approximately 74% of patients receiving 0.4 mg/kg of talquetamab weekly and 73% of those receiving 0.8 mg/kg every other week saw a measurable improvement of their cancer following treatment, the primary endpoint for the trials second phase. That is something which is again, unique, different. loss of voice. The Talquetamab / Daratumumab trial. We would prescribe an ammonium lactate lotion to help with that turnover and also recommend a very heavy moisturizer [such as] Aquaphor or vanicream.. Krina Patel, MD, MSc, discusses research and initiatives that may help to mitigate disparities in patients with multiple myeloma including factors such as gender, race, and ethnicity. Infections also occurred in more than half of patients on each drug dose, with 17% and 12% respectively graded as more severe. [Bispecific antibodies in multiple myeloma]. As with most new agents, assessing and responding to the AEs brought on by novel treatments is critical in ensuring that patients can continue with these therapies. They simultaneously plant a target flag on cancer cells and give immune cells a roadmap to that target. Copyright 2022 Massachusetts Medical Society. (If you just need to know, that stands for G Protein-coupled Receptor class C Group 5 member D.). These are patients whove had typically five lines of therapy over several years. Talquetamab is an investigational, off-the-shelf (ready to use), bispecific T-cell engager antibody targeting both GPRC5D, a novel drug target . Epub 2022 Jun 5. PMC Oral and dermatologic TEAEs, though generally mild, present an opportunity for oncology nurses to improve patient quality of life. Beth Faiman Discusses Recent Changes in Multiple Myeloma Treatment Landscape. The adult patient, for instance, currently needs transfusions to handle her anemia and has intermittent bouts of chronic pain. A decision by the Supreme Court could have far-reaching effects on the lucrative market for antibody drugs, spurring responses from many of the industrys top companies. Editors note: This story has been updated to clarify the status of Vertex and CRISPRs regulatory application. Many patients who reported burning, glossitis, we would treat for candida because our [ear nose and throat] ENT doctor felt that in the setting of such severe dryness, they may not present with oral plaques. 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. 2023 Mar 18;15(6):1839. doi: 10.3390/cancers15061839. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021. Ac., CYT, Enzalutamide, combined with standard treatment, shows promise in prostate cancer, What to know about endometrial stromal sarcoma. Although T cells expressing CD38 might be attacked by AMG 424, this side effect is acceptable because the advantages outweigh the disadvantages . This novel blood clot treatment doesn't increase bleeding risk, Why young women have more adverse outcomes after a heart attack than young men, Gut microbiome appears to fluctuate throughout the day and across seasons, One-hour endoscopic procedure could eliminate the need for insulin for type 2 diabetes, New clues to slow aging? . Conclusions: Disclaimer. The FDA has pushed back the PDUFA date for quizartinib for select patients with acute myeloid leukemia. About two-thirds had skin-related side effects like rash, and around . Both of those therapies bind to BCMA, a protein targeted by a wave of new drugs from Roche, Regeneron, AbbVie and Pfizer. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. In addition, several other studies are underway to assess the use of talquetamab in combination with other existing and investigational multiple myeloma therapies, which could allow patients to have similar or improved benefits, potentially in earlier stages of treatment. New York, NY. Thus, combination therapies may both enhance activity and offer a favorable side-effect profile. Generic Name. Other clinical pearls, according to Aronson, include certain dietary modifications and early treatment of oral candida. Xerostomia . Clinical Updates: Emerging Therapies for Patients With Multiple Myeloma Talquetamab is one of several new drugs in the hopper that are giving us triple+ refractory myelomapatients a heart full of hope. This means that three-quarters of these patients are looking at a new lease on life, said Dr. Chari, of the Tisch Cancer Institute at Mount Sinai in New York. And at the various doses, deep, ongoing responses were noted. Side-Effects of Talquetamab At the time of the data cut-off, 232 patients had received talquetamab (102 intravenously and 130 subcutaneously). Additionally, Shain said that patients on other BiTE therapies may experience an increased risk of infection, as well as rashes, nail issues, loss of taste and other side effects all of which should be brought up to the health care team to ensure that patients can remain on therapy. Also at ASH, Roche and Bristol Myers Squibb presented data for a GPRC5D-targeting bispecific antibody and cell therapy, respectively. Effects of teclistamab and talquetamab on soluble BCMA levels in patients with relapsed/refractory multiple myeloma Blood Adv . Talquetamab binds to both T cells and multiple myeloma cells. But there are six trials recruiting! Janssen is responsible for the development and commercialization of talquetamab. Janssen Submits Biologics License Application to U.S. FDA for J&Js therapy, called talquetamab, is a bispecific antibody aimed at both GPRC5D and a protein expressed by immune cells. Janssen Presents Updated Results Evaluating First-in-Class Talquetamab The .gov means its official. Data showed skin- and taste-related side effects were common, but typically rated mild. The Janssen Pharmaceutical Companies of Johnson & Johnson. According to Aronson, this is an agent with an exciting efficacy profile for a population of patients facing a poor prognosis; at the European Hematological Association Congress 2022, the updated phase 1 findings from the trial showed an overall response rate of 64% to 70%. A Biologics License Application has now been filed with the FDA as the company looks to bringing this novel drug to market as soon as possible. Side effects with talquetamab were meanwhile relatively frequent, but typically mild. ASH 2021: Update on Talquetamab - HealthTree for Myeloma This drug entry is a stub and has not been fully annotated. The range for dosing was biweekly or weekly treatment at a dosage of 1.5 to 180 g/kg with IV administration and 5 to 800 g/kg with subcutaneous treatment. Our dermatologist recommended against do a nail soaks, she noted. J&J's next myeloma drug, Argenx's second act and a new question for Talquetamab (JNJ-64407564) is an investigational bispecific antibody. The . If myeloma stops responding to treatment, it is called refractory myeloma. Results from the TRiMM-2 study of talquetamab (Abstract #161) and teclistamab (Abstract #1647) in combination with DARZALEX FASPRO (daratumumab and hyaluronidase-fihj)will also be presented. and transmitted securely. But neither are expected to give the cash-strapped company significant revenue, making a third program for sickle cell disease crucial to its future. When patients are having taste changes, and their wife is in tears saying I want him to eat, he wont eat, what do I do? Thats where we really can come in and help., Aronson is a clinical nurse practitioner specializing in bone marrow transplant and immune effector cell therapies at Mount Sinai Hospital. Patients would describe this as everything tasting like cardboard or sawdust, or that things that they used to enjoy now tasted completely different.. government site. Oral antihistamines and topical corticosteroids are useful in addressing a body rash and injection-site reactions.
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