Supplements That Are Similar to Ashwagandha. Sleep Sci. hydrochlorothiazide, spironolactone, chlorthalidone). Ashwagandha: Benefits, Side Effects, and More - Verywell Health Take extra care and check with your doctor if you have: Signs of a very bad reaction. A variety of of vitamins and nutritional supplements have been shown to help treat depression. J Ethnopharmacol 1999;64:91-3. Dietary supplements: what you need to know. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. They should also be kept from direct sunlight and stored in their original bottle or container. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. 2001;75(2-3):165-168. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. Headache. glipizide, glyburide, glimepride), SGLT2 Inhibitors (e.g. Cureus 2022;14(10):e30433. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. Ashwagandha Side Effects + Drug Interactions - Vida Optima Ashwagandha supplements are meant to be taken every day. View abstract. Drugs that cause sleepiness and drowsiness are called sedatives. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. Certain antidepressants may not be compatible with herbs or other natural ingredients in these products. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Harvard Health Publishing states that other medications, supplements and your diet all have the potential to affect the way your body processes your antidepressants. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. Acta Nerv Super 1990;32(1):1-5. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Am J Drug Alcohol Abuse 2009;35(1):1-11. Xanax. Dasgupta A, Tso G, Wells A. More are needed for more definitive results. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. A recent study out of India compared varying doses of ashwagandha to a placebo for the treatment of stress. Per the review, five people experienced liver toxicity after taking varying brands and doses of ashwagandha for different lengths of time. of signs you need emergency medical attention or call 911. For this reason, it's always best to tell a healthcare provider if you are taking any medications and/or supplements before starting a new supplement. Select a condition to view a list of vitamins. Effect of Ashwagandha (Withania somnifera Dunal) on the process of ageing on human volunteers. View abstract. This herb used in alternative medicine may help reduce stress. It was concluded that participants from all five studies found improvements in their anxiety. Be sure to tell your doctor if you are breastfeeding. J Funct Morphol Kinesiol. Taking ashwagandha along with these medications might decrease the effects of these medications. View abstract. Cureus 2022;14(10):e30787. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. View abstract. 1981;19(3):245-249. This interference is likely due to a similarity in chemical structure, according to Drugs.com. According to one study that examined ashwagandha's effect on athletics, ashwagandha may improve both endurance and recovery in healthy adult athletes. Indian J Exp Biol. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. Panda S, Kar A. J Neurol Sci 2000;176:124-7. As with many other herbal supplements, little research is available on possible interactions. View abstract. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. View abstract. Talk with a healthcare provider about which herb or supplement may be best for you. Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Last updated Apr 30, 2023 Key points Ashwagandha has not been well studied in regard to potential interactions with prescription medication. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. View abstract. Again, be sure to talk to your doctor about adding ashwagandha to immunosuppressant drugs. It may cause you to become sleepy or drowsy. Can You Take A Z-Pak If You Have A Penicillin Allergy? J Clin Lab Anal 2008;22:295-301. Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Insomnia is a common sleep disorder that is defined as an inability to get adequate sleep. 9-1-2010;10(3):238-246. Read more: 8 Warning Signs of Depression You Shouldn't Ignore. ; Vomiting and nausea. In general, Ashwagandha is thought to be safe when used in moderate amounts. Supplements that are similar to ashwagandha include: It's typically best to take just one supplement or herb at a time for a medical condition. PLoS One. 2013;45(4):417-8. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. View abstract. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Interactions with other substances: ashwagandha may interact with certain medications, supplements, and herbs. 2004;42(12):2015-2020. Ashwagandha interacts with 623 drugs. This article provides a review of the potential uses of ashwagandha. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Does Ashwagandha Interact With Any Medications? An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. Moderate 623 Interactions; Unknown 2123 Interactions; Interaction Rating Key. It may also interact with other herbs, supplements, and even foods. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. Am J Ther 2023;30(1):e80-e83. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Ashwagandha: MedlinePlus Supplements Bull Natl Res Cent. Nutrients. Herbs like Ashwagandha are known to interact with SSRI and other medicines. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. We comply with the HONcode standard for trustworthy health information. These include drugs like thyroid desiccated, levothyroxine, or liotrix. If you're taking antidepressants and vitamins at the same time, be aware of the ingredients in your vitamin supplements. 2020. Which Supplements Should Be Avoided When Taking Statins This is according to a recent review of case studies of liver damage caused by ashwagandha. Commonly prescribed SSRIs include sertraline (brand name Zoloft), paroxetine (Paxil), fluoxetine (Prozac) and citalopram (Celexa). View abstract. Liver Int. Levothyroxine is in the drug class thyroid drugs . Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. View abstract. Take extra care if you are taking drugs to help with your thyroid. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. 1996;35(1):95-100. Benefits of Ashwagandha and How Much To Take - Cleveland Clinic Archana R, Namasivayam A. Antistressor effect of Withania somnifera. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. Ashwagandha: Benefits, Side Effects, Dosage, and Interactions Ahumada F, Aspee F, Wikman G, and et al. Ghosal S, Lal J, Srivastava R, and et al. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Another traditional use of ashwagandha in Ayurveda is for memory issues. Phytomedicine 2000;7(6):463-469. To prolong shelf life, ashwagandha supplements should be stored in a cool, dry place. Ashwagandha is an evergreen shrub that grows in Asia and Africa. Medicine (Baltimore). It is commonly used for stress. The best time to take ashwagandha is at the time that works best for you. 2017 Jan;22(1):96-106 View abstract. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. Effect of a medicinal plant (Passiflora incarnataL) on sleep. It's important to keep all supplements out of reach of small children and pets who may accidentally ingest more than they should. This is called a medicine interaction. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. Created for people with ongoing healthcare needs but benefits everyone. Mandlik Ingawale DS, Namdeo AG. Vitamin Keven in foods such as kale, lettuce, broccoli, and chickpeascan counteract a blood thinner's benefits. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. Ashwaganda is used to treat Herbal Supplementation. 2020;12(2):e7083. J Ethnopharmacol. Cureus. Withania somnifera extract. Antidepressants come in various forms. J Altern Complement Med. View abstract. Although ashwagandha is mainly considered safe, side effects may be possible. Can You Take Lyrica And Flexeril Together? For example, it may increase the sedative effect of medications that treat anxiety and insomnia. Curr Sports Med Rep. 2017;16(4):230-239. doi:10.1249/JSR.0000000000000385. View abstract. Ashwagandha and other dietary supplements should never replace standard medicine or care. As this is a relatively new area of research, more vigorous studies are needed. Does Ashwagandha Interact With Prescription Drugs? If you take a drug meant to suppress your immune systems, such as methotrexate or mycophenolate, they may have conflicting effects. Devi, P. U., Sharada, A. C., and Solomon, F. E. In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Will Ashwagandha Interact With Diabetic Meds These severity listings are for informational use only. The liver damage never progressed to liver failure, and most cases were resolved within five months. Just be sure to choose a supplement from a reputable manufacturer and follow the . Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. View abstract. A total of 203 drugs are known to interact with levothyroxine . View abstract. View abstract. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. These side effects may be mild or severe. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. However, you should not stop taking any prescribed medication. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. Read More. You can also use ashwagandha as an herbal tea. J R Coll Physicians Edinb. Fortunately, no cases resulted in liver failure, and all recovered. Taking ashwagandha along with sedative medications might cause too much sleepiness. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. Side Effects Of Ashwagandha: 5 Things To Be Aware Of - CureJoy View abstract. The news available in this regard in . ashwaganda ashwagandha (Withania somnifera) Entire Monograph Reported Uses Reported Doses Cautions Drug Interactions Adverse Reactions Synonyms Other Info Add to Interaction Check Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. A November 2013 study in the Open Neurology Journal found that vitamin B12 could also help reduce symptoms of depression, while a March 2015 study in the Australian Journal of Herbal Medicine found that several B-complex vitamins could help reduce depressive symptoms. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. The concern would be blood pressure drops too lowif combining high blood pressure medications and ashwagandha. Immunopharmacol.Immunotoxicol. levothyroxine, desiccated thyroid) could potentially increase thyroid hormone levels too much, increasing the risk of side effects. Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone. 2021 Nov 25;13(2):100510. Drug Metabol.Drug Interact. doi:10.7759/cureus.5797, Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. Gastrointestinal side effects including nausea, vomiting and diarrhoea. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. This means they can cause drug-drug interactions, and they can have all the usual side effects and risks that pharmaceutical can have. Ashwagandha - Benefits | Side-Effects | Safety Concerns | Interactions Int.J.Crude Drug Res. Indian J Physiol Pharmacol. Anbalagan, K. and Sadique, J. Lousewort - Amiloride, Hydrochlorothiazide, Cassia Cinnamon - Aspirin, Butalbital, Caffeine, Abuta - Bismuth Subcarbonate, Calcium Carbonate, Opium, English Adder's Tongue - Inotuzumab Ozogamicin, Patricia Kane (pk) Protocol - Indomethacin, Pulsed Electromagnetic Field (pemf) Therapy - Cabozantinib. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Taking it with drugs that increase levels of thyroid hormone (e.g. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. View abstract. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. Altern Med Rev 2000;5:334-46. Unlike people taking SSRIs who can consume most foods without issue, people taking MAOIs need to avoid foods rich in tyramine, a nonessential amino acid. IV. When multiple foods or supplements are processed by your body via the same exact route, they may compete with one another. View abstract. View abstract. Ashwagandha May Interact With Certain Drugs. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Ireland PJ, Hardy T, Burt AD, Donnelly MC. 2009;15(4):423-430. The drug interactions listed above are not all of the possible interactions or adverse effects. View abstract. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). Some benzodiazepine drugs include alprazolam, known as the brand Xanax; clonazepam, known as Klonopin; diazepam, known as Valium; lorazepam, known as Ativan; and triazolam, known as Halcion. Anxiety Medication Interactions: What Should We Be Aware Of - GoodRx Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. Take ashwagandha with these drugs only under your doctor's supervision, recommends the Langone Medical Center at New York University. According to their lab study, withanone may interfere with DNA, leading to liver damage. Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. Its effects on arterial blood pressure in anaesthetized dogs. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. View abstract. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. The most common side effects include: Other less common side effects of ashwagandha include: If you experience side effects when taking ashwagandha, be sure to stop using it and seek advice from a healthcare provider. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. Although, it's important to note that long-term studies have not been performed on ashwagandha. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. ashwaganda: Dosing, contraindications, side effects, and - Epocrates Evid Based Complement Alternat Med. Some evidence suggests that ashwagandha may interact with: Before starting a new supplement, it is vital that you carefully read the ingredients list and nutrition facts panel to know which ingredients and how much of each ingredient is included in the supplement. Ashwagandha might increase how much thyroid hormone the body produces. However, the review noted various limitations of the studies, including study design and potential bias. Take extra care if you are using drugs to help you relax or sleep. This dosing has also been associated with improvements in memory. Myxedema Coma. When people can't obtain all of the nutrients the Food and Drug Administration recommends, they typically look into taking supplements. View abstract. 2020;10(11):e01760. Indian J Exp Biol 2000;38:607-9. Cancer Lett 2000;148:9-17. 2019;11(12):e6466. losartan, valsartan, telmisartan), Beta-Blockers (e.g. Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. Evid Based Complement Alternat Med. I have it on my medical HelloPharmacist There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. Liver damage. J Med Food 2022. In the study, participants received either a placebo or 600 milligrams per day of ashwagandha for eight weeks. 2020;40(4):825-829. Therapeutic Research Faculty 2020. People who are pregnant or breastfeeding should not use ashwagandha. Indian J Pharmacol. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. J Ethnopharmacol. Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. View abstract. However, there is concern that herbs like ashwagandha may have interactions that have . However, even if supplements are third-party tested, they are necessarily safe for all or effective in general. Varying levels of research have looked at the potential benefits of ashwagandha. Ashwagandha might cause sleepiness and drowsiness. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Take extra care driving and doing tasks that you need to be alert for while taking this product. This information does not endorse any treatments or medications as safe, effective, or approved for treating a . Third-party agencies like these confirm that supplements actually contain what they say they do, but they do not approve medical claims. In the study, no adverse events were reported by participants who took the herb. Ashwagandha may be toxic to the liver (hepatotoxic). Of note, the benefits were strongest in those who took at least 600 milligrams per day of ashwagandha for at least eight weeks. Antioxidants (Basel). Aerobic capacity and recovery were assessed for all participants throughout the study. However, there is concern that herbs like ashwagandha may have interactions that have not yet been identified. According to the Mayo Clinic, all of these SSRIs work by blocking the reuptake of serotonin in the brain, which essentially makes serotonin more available. Hydroxyzine has moderate interactions with at least 207 different drugs. Some research has proven that this may indeed be true. Be sure to confirm new supplements fit your dietary needs or preferences. Medically reviewed by Drugs.com. View abstract. Do note that ashwagandha itself does not . 2019;11(9):e5797. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Ashwagandha may interact with various medications. Brain Behav. Go to the ER right away. Several supplements and herbs may act similarly to ashwagandha. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. 1988;26(11):877-882. 2021;18(2):183-226. doi:10.1080/19390211.2020.1741484, D'Cruz M, Andrade C. Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry. . 2021;2:72-81. doi:10.1016/j.crtox.2021.02.002. A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia.
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